منابع مشابه
Drug interaction: Omeprazole and Phenprocoumon
BACKGROUND Oral anticoagulants like the coumarin derivatives are characterised by a particularly narrow therapeutic range. Any interfering co-medication can pose a challenge to establishing a stable anticoagulant dosage regimen and thus present a serious risk for the patient. Here we describe two cases of patients on anticoagulant therapy that suggest possible drug interactions between phenproc...
متن کاملLethargy in a patient with cirrhosis.
Accepted 12 January 1996 In December 1983, a 53-year old Chinese woman presented with a one-year history of generalised pruritus. Various members of her family, extending over four generations, had autoimmunne thyroid disorders. On examination, she had bilateral xanthelasmata but no stigmata of chronic liver disease nor jaundice. Her liver was just palpable but she had neither splenomegaly nor ...
متن کاملIntussusception Presenting with Malignant Hypertension and Lethargy
The most common cause of malignant hypertension in children is renal or renovascular pathology. The combination with lethargy suggests a diagnosis of hypertensive crisis with hypertensive encephalopathy. Here, we present a case of severe hypertension with lethargy as the sole presenting symptoms of ileocecal intussusception. Both normalized following surgical repositioning. We conclude that mal...
متن کاملDrug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer
PURPOSE A microdose drug-drug interaction (DDI) study may be a valuable tool for anticipating drug interaction at therapeutic doses. This study aimed to compare the magnitude of DDIs at microdoses and regular doses to explore the applicability of a microdose DDI study. PATIENTS AND METHODS Six healthy male volunteer subjects were enrolled into each DDI study of omeprazole (victim) and known p...
متن کاملAcid-suppressive effects of generic omeprazole: comparison of three brands of generic omeprazole with original omeprazole.
BACKGROUND Generic omeprazole contains the same active ingredient as original omeprazole and require verification of the bioequivalence with original omeprazole. However, very few clinical studies have been reported. AIMS A prospective, randomised, open-label, crossover study to compare acid-suppressive effect of generic omeprazole with that of original omeprazole. SUBJECTS Seven healthy He...
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ژورنال
عنوان ژورنال: BMJ
سال: 1997
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.314.7079.481a